Breakthrough infection after COVID-19 vaccination: A threat for Nepal due to SARS-CoV-2 variants circulating in 2nd wave ravaging India

After a year of the COVID-19 pandemic, meta-analysis in Dec 2020 did not support its reinfections. Now it’s clear that only reinfection following earlier exposure is reality, but also breakthrough infections after vaccinations have been increasingly reported. A infection means has broken through protection provided by vaccine. The course disease, strict observation for preventive measures, together with safe vaccines necessary long-term solutions. effectiveness vaccine, durability immunity, role virus variants, incidence and severity are challenges real life. detection SARS-CoV-2 RNA or antigen respiratory specimen ≥14 days inoculation 0.04 to 13% reported literature. Nepal began vaccine rollout late Jan 2021. Nearly 3 million population vaccinated two vaccines, Covishield (AstraZeneca, from India) Vero Cell (Sinopharm, China). Only minor ‘Adverse Event Following Immunization’ initial There lack reports on these local population. Analysis data rollouts awaited.